混合ハーブ抽出物と2つの生薬からなる新規ハーブ混合物の抗糖化作用 : 短期および長期の影響

概要

論文の詳細を見る
The anti-glycation effect of mixed herbal extract (MHE) was already reported. HME was produced using hot water extraction from Anthemis nobilis (Roman chamomile), Crataegus oxyacantha (hawthorn berry), Houttuynia cordata (dokudami), and Vitis vinifera (grape leaf). MHE can be regarded as a Chinese herbal remedy. In Chinese herbal remedy, it is well known that a little of additional crude drugs can change the original effects. We assessed whether a capsulated novel remedy of MHE with Zingiber officinale (syouga) and Zanthoxylum piperitum (sansho) showed an anti-glycation effect. We also assessed its effects on one's quality of life (QOL). The subjects consisted of 12 volunteers divided into two groups, the Normal Blood Sugar (NBS) Group (male: 1; female: 7; age: 47.3 ± 10.2 years) and the Diabetes Mellitus / Impaired Fasting Glycaemia (DM/IFG) Group (male: 3; female: 1; age: 51.5 ± 12.7 years) with HbA1c 5.7〜7.0. Both of the Groups were administered 240 mg of MHE (solid substance) with certain amounts of Zingiber officinale (syouga) and Zanthoxylum piperitum (sansyo) in 4 capsules per day for 12 weeks. Two individuals - one of NBS Group and the other of DM/IFG Group - were administered continuously for 80 weeks. The inhibition of glycation was assessed by AGE reader^<TM>, non-invasively measuring the advanced glycation endproducts (AGEs) as skin auto fluorescence (AF). Also the skin elasticity was assessed by Cutometer. The analysis using the Anti-Aging QOL Common Questionnaire (AAQol) showed that the score for the parameters, "constipation", "cold skin", and "weight loss; thin" were significantly improved or changed (p=0.043). The skin AF decreased in the both Groups after 8 and 12 weeks respectively, and significant variation (p=0.020) was observed in the NBS Group after 12 weeks. Continuous intake for 80 weeks revealed continuing low values of skin AF. Stopping the intake at 12 weeks resulted in a deterioration of skin AF. The skin elasticity index R2 in the DM/IFG Group showed a slight improving tendency after 12 weeks. The novel remedy of MHE with additional two crude drugs inhibited the accumulation of AGEs in the skin. These results suggest that a continuous supplementation of the test product was considered to be a safe anti-glycation method.

混合ハーブ抽出物と2つの生薬からなる新規ハーブ混合物の抗糖化作用 : 短期および長期の影響

スポンサーリンク

概要

著者

関連論文

スポンサーリンク