クローブ(syzygium aromaticum L.)熱水抽出物の高脂肪食摂餌マウス脂質代謝に及ぼす影響

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The effect of a hot water extract of clove (Syzygium aromaticum L.) on serum and hepatic lipids, and fecal triglyceride levels was investigated in mice. The addition of 1.0% (w/w) of the clove hot water extract to a high-fat diet containing 60% (w/w) lard for 28 days significantly increased fecal triglyceride levels, significantly reduced plasma insulin and hepatic total cholesterol levels, and tended to reduce plasma and hepatic triglyceride levels compared with mice given a high-fat diet without the clove hot water extract. Semiquantitative real time reverse transcription-polymerase chain reaction analysis demonstrated that addition of the clove hot water extract to a high-fat diet increased gene expression of medium-chain acyl-CoA dehydrogenase and reduced gene expression of fatty acid synthase in the liver. In addition, the clove hot water extract dose-dependently inhibited lipase activity in vitro. It is therefore suggested that the improvement action of lipid metabolism in mice fed a high-fat diet originated from the activation of lipid oxidation, the inactivation of fatty acid synthesis in the liver, and the inhibition of lipolysis in the small intestine.
2007-08-20