液-液界面晶析法を用いた有機・無機ハイブリッド粒子の作製

概要

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Liquid-liquid interfacial crystallization is the process in which crystals are precipitated on a liquid-liquid interface. This method enables us to crystallize solute materials at normal and constant temperature without heating or cooling. Therefore, the applications to fields of medicine and food that use a number of organic substances such as a protein of denaturation by heat can be expected. This method has some advantages that the degree of supersaturation in solutions can be maintained comparatively uniform and crystals are producible in a short time. As reported in the past, it is confirmed that it is possible to produce porous particles by forming droplet interfaces in atomization processes. Our research involved producing glycine-silica hybrid particles by atomizing glycine solution containing silica particles into 1-butanol. The glycine solution/1-butanol interface was formed on the silica particle by wetting the silica surface with glycine solution and contacting the solution with 1-butanol. As a result, glycine crystals were precipitated on the surface of the silica and glycine-silica hybrid particles were obtained in this atomization process. In addition, the most unstable β-glycine could be precipitated by the liquid-liquid interfacial crystallization, and transformation from the unstable β-glycine to the metastable α-glycine occurred by solution-mediated transformation.