非血縁者間同種末梢血幹細胞移植(<特集>アフェレシスの新しい適応をめぐって)

概要

論文の詳細を見る
Allogeneic peripheral blood stem cell transplantation (PBSCT) as well as allogeneic bone marrow transplantation (BMT) is a curative treatment strategy for patients with hematopoietic disorders. PBSCT is associated with more rapid hematopoietic recovery than BMT. Although PBSC harvest is feasible without the risk of anesthesia or invasive multiple bone marrow aspirations, the other concern is the short-term and long-term safety. In a nation-wide prospective survey of the Japan Society for Hematopoietic Cell Transplantation and other worldwide registry data, PBSC harvest was mostly tolerated as well as BM collection. Both patients and donors have more therapeutic options for unrelated donor transplantation with the use of PBSC. However, some problems (safe procedure for donor, inspection and accreditation of hospital, work-sharing, apheresis center, management of post-transplantation, cryopreservation, etc.) should be dealt with.
2010-10-31