T1601-2-1 VEGF含有ビーズを用いたマイクロ流路への脈構造誘導形成に関する研究(マイクロナノダイナミクスの計測と制御・マイクロナノメカトロニクス(2))

概要

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We propose a novel concept that self-organized vasculature integrates artificial orifices on a microfluidic device using inducible protein VEGF (Vascular Endothelial Growth Factor) for fluid induction into vasculature. Micro gel beads containing VEGF immobilized on orifices, it is able to induce angiogenesis to orifices on embedded channels. Endothelial cells (HUVEC) characteristically organize vasculature by themselves in collagen gel and grow along the VEGF concentration gradient. HUVEC were cultured on the device for a day in collagen gel and vasculature was forming on orifices by self-organized. And angiogenetic effect was evaluated quantitatively.
社団法人日本機械学会の論文
2009-09-12