J0401-4-1 TNTZチタン合金の生体親和性に関する研究 : 緬羊人工骨頭における組織反応と金属元素の溶出(生体材料およびその表面改質材(4))

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As a new biomedical metal, low rigidity titanium alloy of Ti-29Nb-13Ta-4.6Zr (TNTZ) was developed where all elements are considered as non-toxic. As a practical in-vivo study with sheep, Press fit (Cement-less) femoral head prosthesis was made out of TNTZ, and femoral head replacement (FHR) was performed in 2 sheep labeled as #1 #2 And histopathological observation and metal element analysis were performed on the surrounding tissue and internal organs. FHR of sheep #1 failed in the fixation by the under sizing, and resulted in severe loosening. FHR of sheep #2 was succeeded in the fixation by the suitable sizing. The low rigidity titanium alloy of TNTZ seemed to be a promising material to improve the load transmission, and retain the stable prosthetic fixation with no bone atrophy. Metal ion release can be caused by the relative movement due to articulation or loosening. However there were no pathological findings due to the metal elements in the internal organs and bone tissue.
2009-09-12