免疫異常による神経疾患(神経-免疫-内分泌,<特集>東京女子医科大学学会第61回総会)

概要

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Multiple sclerosis (MS) is thought to be an autoimmune disease mediated by T cells respond to central nervous myelin antigens including myelin basic protein (MBP) and proteolipid protein because of their encephalitogenic potentials in experimental autoimmune encephalomyelitis, animal model of MS. We report a higher frequency of T cell lines reactive to MBP between residues 84-102 in patients with MS in both Caucasians and Japanese, so it is likely that MBP reactive T cells for this region have an important role in the etiology of patients with MS. Guillain-Barre syndrome (GBS) in which anti-glycolipid antibodies were proved in recently years is considered as another typical neuroimmunological disease however it is still examined whether anti-neuronal antibody (ANA) is a primary cause of demyelination in GBS. In addition to GBS, other specific ANAs were detected in paraneoplastic neurological syndrome such as LambertEaton myasthenic syndrome, paraneoplastic cerebellar degeneration and paraneoplastic sensory neuropathy. And investigations of such ANAs in the various neuroimmunological disorders are becoming useful diagnostic tools.
東京女子医科大学の論文
1996-04-25