多発性硬化症における感染因子の意義(神経内科学教室竹宮敏子教授退任記念特別号)

概要

論文の詳細を見る
Multiple sclerosis (MS) is a demyelinating disease of unknown origin. Some kind of infection was thought to disturb the immune regulation in a person susceptible to MS and has also been extensively examined as an influential factor in the etiology of MS. Though the infectious agent including various viruses was mentioned as a candidate, the clear relevance to MS has not been proven. There is the report of endogenous retrovirus, herpes viruses such as EBV and HHV-6, and Chlamydia as infectious agents which may be concerned with the onset of MS after 1990. Ideas such as antigen spreading and molecular mimicry between the protein of microorganisms and myelin antigen have been presented to consider the pathogenesis of MS. Here, I reviewed recent reports on the infectious agent in MS and tried to summarize the relation between the infectious agent and MS.
東京女子医科大学の論文
2000-12-30