Low-dose CDDP/5-FU療法が奏功した切除不能再発大腸癌の3例

概要

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Three cases of inoperable recurrent colorectal cancer that were successfully treated with low-dose cisplatin (CDDP) and 5-FU chemotherapy are herein reported. The chemotherapy regimen consisted of CDDP (5 mg/day div. days 1～5) and 5-FU (200～450 mg/m^2/day div, days 1～5) during a 6-week period. A partial response was observed in all three cases. An adverse reaction higher than grade 3 was seen in only one case who had grade 3 leukocytopenia. However, the reaction was not severe and it also was generally well tolerated. No renal toxicity was recognized. We thus concluded that low-dose CDDP and 5-FU therapy is a safe and useful chemotherapeutic regimen for patients with inoperable recurrent colorectal cancer.
東京女子医科大学の論文
2003-06-25