EFFECT OF 3-AMINO-1H-1,2,4-TRIAZOLE OF LOW IODINE DIET ON RAT THYROID CARCINOGENESIS INDUCED BY ETHYLENETHIOUREA

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Six group of female outbred Wister rats were subjected to the following treatments for 60 weeks: administration of 250 ppm ethylenethiourea in combination with 3-amino-1H-1,2,4-triazole (amitrole) in the drinking water (group I) or low iodine diet containing 0.25 ppm of iodine (group II); 250 ppm ethylenethiourea alone administered in the drinking water (group III); 2500 ppm 3-amino-1H-1,2,4-triazole alone in the drinking water (group IV); low iodine diet and tap water (group V); and basal diet containing 5 ppm of iodine and tap water (group VI). Animals that survived for more than 30 weeks from the beginning of the experiment were included as the effective number. Goiters which were defined as enlargement of the thyroid due to hyperplasia of the follicular tissue, developed in all rats given ethylenethiourea, amitrole or lowiodine diet (groups I-V). Follicular carcinoma with invasive growth of small follicles through the capsule and into adjacent adipose and muscular tissues and pericapsular blood vessels was found in significantly high incidences in these groups. Pulmonary metastases were found in two rats given ethylenethiourea singly. Dysplastic nodules composed of atypical small cells with basophilic cytoplasm and hyperchromatic nuclei were found in groups I to IV (p<0.05) and never in groups V and VI. The development of follicular carcinoma showed tendency to be inhibited by feeding low iodine diet. A significantly decreased incidence of dysplastic nodules was demonstrated by the combined administration of amitrole or low iodine diet with ethylenethiourea. Synergistic effects in the development of follicular carcinoma were failed to demonstrate between ethylenethiourea and amitrole or low iodine diet.
名古屋市立大学の論文
1978-11-28

EFFECT OF 3-AMINO-1H-1,2,4-TRIAZOLE OF LOW IODINE DIET ON RAT THYROID CARCINOGENESIS INDUCED BY ETHYLENETHIOUREA

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