ULTRASTRUCTURAL STUDY OF CHANGES OF THE BASEMENT MEMBRANE AND CAPILLARIES OF THE URINARY BLADDER IN RATS INDUCED BY N-[4-(5-NITRO-2-FURYL)-2-THIAZOLYL] FORMAMIDE

概要

論文の詳細を見る
The effect of oral N-[4-(5-nitro-2-rnryl)-2-thiazolyl]-formamide (FANFT) on the epithelium and mesoderm of growing rat was examined. Male 4-week-old Fischer wats were given diet containing 0.2% FANFT for 20 weeks and then maintained on control diet. The bladder was examined at 2 week intervals during the 20 week feeding period, and then in week 52 by electron microscopy. After 4 weeks of FANFT feeding, the basal margin of the basal cells of the bladder epithelium had a zigzag appearance with increased hemidesmosomes. After 8 weeks it had a markedly serrated appearance and capillary vessels were fenestrated. After 20 weeks and also after 52 weeks, the lamina densa had formed 2 or more layers. The basement membrane had become discontinuous with extensive fenestration and numerous layers of electron dense material had appeared. The abnormal appearance of the basement membrane and the neovascularization may be markers of preneoplastic changes in tumor formation.
名古屋市立大学の論文
1980-03-30