1. フリーズドライの新分野への応用について(第5報) : 凍結乾燥コリスチンの食品用殺菌剤への応用とその製法

概要

論文の詳細を見る
In the previous paper, we reported a lyophilizing method for injection preparations of antibiotic colistin salt and colistin sodium methanesulfonate which are suitable for the dissolution. In this study, we investigated the transfer process of lyophilized colistin sulfate and colistin sodium methanesulfonate by administering orally a large quantity of these antibiotics to beagles, because colistin salts are appreciated to be scarcely absorbed through the intestinal tract. The transfer of colistin sulfate to the blood was far less than that of colistin sodium methanesulfonate, and it seemed that most of colistin sulfate was discharged into faeces. We also report a method for freeze-drying a large quantity of colistin sulfate efficiently and without lowering its activity by improving the conventional dryer for the purpose of using colistin sulfate as a preservative additives for foods. We developed the colistin block lyophilization method, and the colistin raw meat ball by using freeze-dried new binding materials.
低温生物工学会の論文
1994-12-27