1. フリーズドライの新分野への応用について(第2報) : (2) 生理活性物質コリスチンの凍結乾燥(平成3年度第37回凍結及び乾燥研究会研究報告)

概要

論文の詳細を見る
Colistin, a kind of antibiotics, is effective against gram negative bacteria. In this study, Colistin-sulfate and Colistin-citrate were manufactured as its salt, and Colistin sodiummethanesulfonate was also munufactured as its derivative. Then, they were freeze-dried. In the process of freeze-drying, rapid freezing was necessary to prepare the fusible powder. Physiological functions were maintained when they were freeze-dried at the temperature below the eutectic point. However, the temperature was raised during the process in three steps, starting from -40℃ to 55℃ finally, as it would take a long time if the temperature should be kept below the eutectic point.
低温生物工学会の論文
1991-10-20