放射性同位元素による唾液腺内分泌の影響

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Material and methods: The following 5 groups of the rats were prepared for their experiments. [A-group] The rats which were removed parotid and submaxillary salivery glands totaly. (asialadenism) [H-group] Submaxillary salivery glands removed group, in which the parotid gland hypertrophied compensatory (hypersialadenism). [A'-group] Parotid grand removed, (hyposialadenism). [P-group] The group of the asialadenism rats which received "parotin" at daily dossage of 0.3 mg per 100 g body weight subcutaneouly for 1 month. [K-group] The normal rats. 1) These groups of the rats (K, H, A and A') were divided into three categories such as, 14 month, 3 months and 6 months after the remoueness of salivery glands. Each group, consisted to 2〜5 mice, received the injection of 0.01 μc of P32 in the form of potassium phosphate per 100 g body weight. 2) Ca^<45> was injected to the group of the rats (K, H, A and A') which classified as follows according to the post operative period such as, 3, 6 and 12 months. Thirdly, P, A, and K-group were injected 1 month after the operation and made a comparative study of each group. 3) The distribution of the radioactive P^<32> and Ca^<45> in a humerus was examined 24 hours after the injections by Geiger-Muller counter, arid femur was examined by a autoradiography. The tibia was also examined histologically about some of the rats. Results: 1) The results on the weight are as follows. During the postoperative period of 1 1/2 month, the heaviest group was H, and then follow as K, A and A'-group. The difference between A and A' was minimal. During the post operative period of 3 months, the heaviest group was still H, but the rest of the groups were interchanged as follows A', K and A-group. There was no significant difference among these groups 6 months after operation. 2) Among the rats of H-group which devieded as 1 month, 3 months and 6 months according to the period of follow up, the increase of deposit of P^<32> and Ca^<45> in their epiphysis of the tidia was remarkable to compare the K-group rats. The Ca^<45> in blood was significantly decreased among the H-group rats but the P^<32> in blood was all within normal limit. 3) Among the rats of A-group unexpectedly, the depositing of the P^<32> into epiphysis of the tibia was unchanged, but decreased Ca^<45> were noticed untill 3 months. There was no significant change about the Ca^<45> and P^<32> in blood among the A-group rats. 4) No change was observed between A'-group rats and K-group rats about the deposition of Ca^<45> and P^<32>. 5) In the P-group of rats, deposit of Ca^<45> was nearly the same as K-group.
千葉大学の論文
1959-09-28

放射性同位元素による唾液腺内分泌の影響

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