同時注射による定量的ツベルクリン反応の研究

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In his report on a simultaneous serial test for tuberculin reaction, Shindo (Institute for Infectious Diseases, Tokyo University) has recently stated that there was a considerably high incidence of subjects in whom an abnormal phenomenon of tuberculin reactions occurred-an abnormal reaction that a reaction to 1 : 2000 dilution of tuberculin is negative but reactions to higher dilutions are positive in the same individual. Assuming that the theory of optimal ratio of antigen and antibody also applies in tuberculin reactions in humans, he assarted that the abnormal phenomenon represented the zone phenomenon of tuberculin reactions. The question posed before us is of sifnificance, for if his assertion should be corroborated, our decision to use the dilution 1:2000 in the tuberculin reaction test for the diagnosis of tuberculosis infection would have to be reconsidered, causing a great deal of confusion among those concerned in the prevention and treatment of tuberculosis. We carried out a simultaneous serial test for tuberculin reactions in a wide range of subjects, including primary school and junior high school students, female workers at a woollen textile mill, and tuberculous and nontuberculous patients hospitalized in our clinic. The test consisted in the injection of varying dilutions of tuberculin (1:500, 1:2000, 1:16000 and 1:32000); the subjects undergoing the test were divided into two groups, one group receiving injections at the area of the skin where tuberculin injections had repeatedly been made previously and the other group at the area where tuberculin injections had never been made. In order to see whether the so-called abnormal phenomenon had occurred, reactions of each individual to verying dilutions of tuberculin were examined after 24, 48 and 72 hours in all the subjects under study except for textile workers. The results of experiments are summarized as follows : (1) There was no one who produced evidence of the abnormal phenomenon that a reaction of an individual to the dilution 1:2000 was negative but his reactions to higher dilutions (1:16000 and 1:32000) were positive. (2) Reactions to varying dilutions of tuberculin of some of the subjects who had positive test with the dilution 1 :2000 might be said to be contradictory to one another if the intensity of reactions were to be determined solely on the basis of the diameter of the portion of the skin where reddenning had occurred. When the results of injections were judged on the basis of the overall intensity of reactions, taking into consideration the degree of induration and double reddenning of injected sites, it was shown that reactions to higher concentrations of tuberculin were more intensive than reactions to lower concentrations. In view of these observations, we are convinced that there is no possibility of the abnormal phenomenon occurring in tuberculin reactions-the abnormal phenomenon that the reactions of an individual to lower concentrations of tuberculin are more intensive than his reactions to higher concentrations.
千葉大学の論文
1958-05-28

同時注射による定量的ツベルクリン反応の研究

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