Meta-analysis Study for One Year Effects of a Nicotine Patch
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概要
- 論文の詳細を見る
Smoking is a risk factor for various disorders. Strategies have been established in various countries. To support smoking cessation, the nicotine patch was developed, and various clinical studies have been conducted to evaluate its effects. However, its long-term effects remain to be clarified. We conducted a meta-analysis based on the results of randomized, comparative studies, with high-level scientific reliability, to investigate the long-term efficacy of the nicotine patch. We reviewed the 1-year results of nicotine-patch use in 18 studies using a fixed effect model via the PubMed and Cochrane Library. The combined odds and risk ratios were 1.753 [95% confidence interval (CI): 1.520-2.021] and 1.594 (95% CI: 1.406-1.806), respectively. In the nicotine-patch group, the success rate for smoking cessation was significantly higher than that in the nicotine-patch-free group. Furthermore, the combined risk difference was 5.33% (95% CI: 3.99-6.66%); nicotine-patch prescription increased the rate at which smoking cessation was successfully achieved, by approximately 5%. The number of persons requiring treatment after 1 year was 19. Based on the results of RCTs, we calculated the combined odds ratio, combined risk ratio, combined risk difference, and number needed to treat (NNT). The nicotine patch significantly increased the success rate for smoking cessation after 1 year. The possibility of publication bias cannot deny completely because the funnel plots were not symmetrical.
- 2009-04-01
著者
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MUTO Takashi
Department of Public Health, Juntendo University School of Medicine
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Kimura Kazumoto
Center for Medical Informatics, Dokkyo Medical University Hospital
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Sairenchi Toshimi
Department of Public Health, Dokkyo Medical University
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Muto Takashi
Department Of Public Health Dokkyo Medical University School Of Medicine
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Sairenchi Toshimi
Department Of Pubic Health Medicine Dokkyo University School Of Medicine
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Sairenchi Toshimi
Department Of Public Health Dokkyo Medical University
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Kimura Kazumoto
Center For Medical Informatics Dokkyo Medical University Hospital
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