混合溶媒系におけるリン脂質の解離定数の決定 : 第一報 75%ジオキサン溶液中におけるLecitinの電位差滴定

概要

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To get better information about the dissociation states of lecithin in water-dioxan solvent system, following experiments were curried out. (1) Confirming the corelation of indication of the glass electrode and the standard hydrogen electrode, through the titration of hydrochloric acid in mixed soluent. (2) Evaluation of the primary medium effect of the soluent. From these data, hydrogen ion-activity in mixed solvent was measured by normal glass-calomel eledrode system, and the difference between the indication of pH meter in water and in mixed solvent was corelated to the composition and concentration of ions in the solution. And, for pre-experiment, the dissociation constant of acetic acid was determined in 75% dioxan solvent. (3) After these operations, the detemination of pk values of lecithin was curried out in the same solvent showing (3.84±0.04) for pK_a and (11.33±0.11) for pK_b respectively.
仙台大学の論文