1104 動脈壁における物質透過を考慮したImage-Based血流解析(S02-1 循環器系・呼吸器系の生体機能モデリング(1),S02 循環器系・呼吸器系の生体機能モデリング)

概要

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Atherosclerosis is one of the causes of cardiovascular diseases or celebrovascular disorders. Low density lipoprotein transport through an arterial wall and accumulation is considered as a main factor in the early stage of initiation of atherosclerosis. On the other hand, it is known that mechanical forces such as wall shear stress (WSS) influence the uptake function of endothelial cells and the preferential site of atherosclerosis is associated with low wall shear stress region. In this paper, to investigate the effects of wall shear stress on mass transport, the blood flow and solute transport in the lumen and arterial wall are modeled taking account of the multi-layered structure of arterial wall. A shear-dependent hydraulic conductivity and permeability is employed. As a result, solute concentration in arterial wall increases in the areas where wall shear stress is low. It shows that low wall shear stress affects solute accumulation in the arterial wall and initiation of atherosclerosis.
社団法人日本機械学会の論文
2007-09-07