21回のI-131内照射療法により30年以上の生存を得た甲状腺濾胞癌骨転移の一症例

概要

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21 courses of Iodine-131 (I-131) therapy were given over a period of 30 years to a patient with follicular thyroid carcinoma and metastatic sacral bone tumor. The cumulative quantity of I-131 reached 86.17GBq. This series of I-131 treatment achieved good control of the sacral bone metastasis. Although the cumulative radioactivity dose of I-131 was high, the patient had no symptomatic pulmonary fibrosis, myelosuppression, or leukemia. The patient eventually developed bladder carcinoma, and died of this disease. Although a causal link between I-131 therapy and bladder carcinoma could not be confirmed, exposure to I-131 radiation may have been the cause of the urinary tract carcinoma. In cases treated with a total dose of I-131 exceeding the usual maximum dosage of 37GBq, the risks of secondary cancer should be considered.原著Original Paper
東北大学の論文