Synthesis, Characterization and DNA-Binding Properties of the Cu(II) Complex with 7-Methoxychromone-3-carbaldehyde-benzoylhydrazone

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概要

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• A new chromone derivative (7-methoxychromone-3-carbaldehyde-benzoylhydrazone) ligand (HL) and its novel Cu(II) complex have been synthesized and characterized on the basis of elemental analyses, molar conductivities, proton nuclear magnetic resonance, infrared spectra and mass spectra analyses. The general formula of the Cu(II) complex is [CuL(HB_<2B>O)]Cl・2H_2O. In addition, the interaction of the Cu(II) complex and its free lig- and with calf-thymus DNA was investigated by electronic absorption spectroscopy, fluorescence spectroscopy and viscosity measurement. Results suggest that both the two compounds can bind with calf-thymus DNA via an intercalation mechanism. Furthermore, the Cu(II) complex can bind to DNA more strongly than the free ligand due to the chelating effect of copper(II) ion to the free ligand.

• 社団法人日本薬学会の論文
• 2009-01-01

著者

• Qi Gao-fei

  College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry

• YANG Zheng-Yin

  College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry,

• QIN Dong-Dong

  College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry,

• Yang Zheng-yin

  Coll. Of Chemistry And Chemical Engineering And State Key Lab. Of Applied Organic Chemistry Lanzhou

• Yang Zheng-yin

  College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry

• Qin Dong-dong

  College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry

関連論文

• Synthesis, Characterization and DNA-Binding Properties of the Cu(II) Complex with 7-Methoxychromone-3-carbaldehyde-benzoylhydrazone
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