Synthesis, Thermodynamics Stability Constant and Relaxation Properties of Neutral Gd(III) Complex with Derivative from Diethylene Triamine Pentaacetic Acid and p-Hydroxybenzoyl Hydrazine
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概要
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A novel ligand, diethylenetriamine-N,N"-bis(acetyl-p-hydroxybenzoyl hydrazine)-N,N',N"-triacetic acid (H_3L) was synthesized and characterized on the basis of elemental analysis, molar conductivity, ^1H-NMR spectrum, FAB-MS, TG-DTA analysis and IR spectrum. Its complex of Gd(III) holding promise of magnetic resonance imaging (MRI) was synthesized, and relaxivity (R_1) of complex and Gd (DTPA)^<2-> used as a control was determined in water solution, respectively. The relaxivity of GdL (R_1=6.391・mmol^<-1>・S^<-1>) was larger than that of Gd (DTPA)^<2->(R_1=4.341・mmol^<-1>・s^<-1>). The relaxivity of GdL has also been investigated in human serum albumin (HSA) solution, the relaxivity of GdL was enhanced from 6.391・mmol^<-1>・s^<-1> in water solution to 7.691・mmol^<-1>・s^<-1> in HSA solution. In addition, thermodynamics stability constant of GdL was determined. The results showed that complex of GdL is a prospective MRI contrast agent, although the thermodynamic stability constant of GdL complex (K_<GdL>=10^<19.56>) was a little less than that of Gd (DTPA)^<2->(K_<Gd-DTPA>=10^<20.73>).
- 社団法人日本薬学会の論文
- 2006-03-01
著者
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Zhang Shi-Ping
State Key Laboratory of Natural and Biomimetic Drugs, Peking University
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Zhang Shi-ping
State Key Laboratory Of Applied Organic Chemistry College Of Chemistry And Chemical Engineering Lanz
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ZHANG Ding-Wa
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering Lan
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YANG Zheng-Yin
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering Lan
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YANG Ru-Dong
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering Lan
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Yang Zheng-yin
Coll. Of Chemistry And Chemical Engineering And State Key Lab. Of Applied Organic Chemistry Lanzhou
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Zhang Ding-wa
State Key Laboratory Of Applied Organic Chemistry College Of Chemistry And Chemical Engineering Lanz
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Yang Ru-dong
State Key Laboratory Of Applied Organic Chemistry College Of Chemistry And Chemical Engineering Lanz
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Zhang Shi-ping
State Key Lab. Of Natural And Biomimetic Drugs Peking Univ.
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