DNA-Binding Properties Studies and Spectra of a Novel Cu(II) Complex with a New Coumarin Derivative
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概要
- 論文の詳細を見る
A new coumarin derivative (8-methylcoumaro-4a,10a-pyrone-3-carbaldehyde benzoyl hydrazone) ligand and its novel Cu(II) complex have been synthesized and characterized on the basis of elemental analyses, molar conductivities, ^1H-NMR, IR spectra, UV-visible spectroscopy and thermal analyses. In addition, the interactions of the Cu(II) complex and the ligand with calf-thymus DNA were investigated by spectrometric titrations, ethidium bromide displacement experiments and viscosity measurements. It was found that both the two compounds, specially the Cu(II) complex, strongly bind with calf-thymus DNA, presumably via an intercalation mechanism.
- 社団法人日本薬学会の論文
- 2008-04-01
著者
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Qi Gao-fei
College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry
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YANG Zheng-Yin
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry,
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QIN Dong-Dong
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry,
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WANG Bao-dui
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry,
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LI Tian-rong
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry,
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Yang Zheng-yin
Coll. Of Chemistry And Chemical Engineering And State Key Lab. Of Applied Organic Chemistry Lanzhou
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Yang Zheng-yin
College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry
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Wang Bao-dui
College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry
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Li Tian-rong
College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry
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Qin Dong-dong
College Of Chemistry And Chemical Engineering And State Key Laboratory Of Applied Organic Chemistry
関連論文
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- DNA-Binding Properties Studies and Spectra of a Novel Cu(II) Complex with a New Coumarin Derivative
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