Phosphorylation of Nucleosides and Nucleotides with Inorganic Monoimido-cyclo-Triphosphate
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概要
- 論文の詳細を見る
The phosphorylation of nucleosides (adenosine, guanosine, cytidine, and uridine) and nucleotides (adenosine 5'-monophosphate, guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate) has been achieved using inorganic monoimido-cyclo-triphosphate (MCTP, Na_3P_3O_8NH) in aqueous solution. In this reaction, the 2'-OH or 3'-OH group of the β-D-ribofuranose unit was phosphorylated and the total yield was more than 30% and 14%, respectively. The main products were 2'-diphosphoramidophosphononucleoside and 2'-diphosphoramidophosphononucleoside 5'-monophosphate.
- 公益社団法人日本薬学会の論文
- 2008-12-01
著者
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TSUHAKO Mitsutomo
Department of Chemistry, Kobe Pharmaceutical University
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CHIBA TAKESHI
Department of Neuropsychiatry, Hirosaki University School of Medicine
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NAKAYAMA HIROKAZU
Department of Biology, Graduate School of Science, Osaka City University
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Chiba Takeshi
Department Of Functional Molecular Chemistry Kobe Pharmaceutical University
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MAEDA Hideko
Department of Functional Molecular Chemistry, Kobe Pharmaceutical University
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Maeda Hideko
Department Of Functional Molecular Chemistry Kobe Pharmaceutical University
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Tsuhako Mitsutomo
Department Of Chemistry Kobe Pharmaceutical University
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