Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis(BIOINFORMATICS)
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概要
- 論文の詳細を見る
Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-dependent kinases, and other proteins. Numerical simulation techniques and system analysis are expected to become powerful tools for investigating complex biological networks. To reach this goal, we designed a mathematical model of the G1/S phase transition. Using our model, we conducted a numerical simulation and comprehensive system analyses of this phase of the cell cycle. In this way, we were able to predict the key factors involved in the control of the G1/S transition.
- 社団法人日本生物工学会の論文
- 2008-10-25
著者
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OKAMOTO Masahiro
Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sc
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HAMADA Hiroyuki
Laboratory of Plant Pathology and Biotechnology, Faculty of Agriculture, Kochi University
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Hanai Taizo
Laboratory For Bioinformatics Graduate School Of Systems Life Sciences Kyushu University
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Hanai Taizo
Laboratory For Bioinformatics Graduate School Of System Life Sciences Kyushu University
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Tashima Yoshihiko
Laboratory for Bioinformatics, Graduate School of Systems Life Sciences, Kyushu University
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Tashima Yoshihiko
Laboratory For Bioinformatics Graduate School Of Systems Life Sciences Kyushu University
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Hamada Hiroyuki
Laboratory For Bioinformatics Graduate School Of Systems Life Sciences Kyushu University
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Okamoto Masahiro
Laboratory For Bioinformatics Graduate School Of Systems Life Science Kyushu University:laboratory O
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