GOBLET CELL HYPERPLASIA ELICITED BY INFECTION WITH AN INTESTINAL NEMATODE, STRONGYLOIDES VENEZUELENSIS, IS NOT PROTECTIVE AGAINST GOBLET CELL-SENSITIVE NIPPOSTRONGYLUS BRASILIENSIS IN MICE.

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Intestinal nematode infections usually elicit similar pathological changes in the intestinal mucosa, regardless of the parasite species. Because Th2 cytokines, such as IL-4, IL-5, IL-9, and IL-13, are produced simultaneously, similar cellular responses occur in a number of parasitic infections. In Strongyloides venezuelensis infection in mice, goblet cell hyperplasia was induced after infection as expected. However, the goblet cells induced in S. venezuelensis infection was not protective against another intestinal nematode, Nippostrongylus brasiliensis, whose expulsion was tightly associated with goblet cell hyperplasia. Lectin histochemistry revealed that there was no evidence for the sialation of mucin sugars, although the structure of goblet cell mucin changed after S. venezuelensis infection. Because N. brasiliensis infection induces highly sialated goblet cell mucin, not only Th 2 cytokines but specific factors from N. brasiliensis adult worms might be required for the sialation of intestinal goblet cell mucin.
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