ヒト有郭乳頭の成長発育におけるVEGFの局在

概要

論文の詳細を見る
Expression of Vascular endothelial growth factor (VEGF) was investigated on the developing human circumvallate papillae by immunohistochemistry. At fetal 16 weeks, immunoreactivity of VEGF was detected on many cells at epithelial and mesenchymal tissue in the circumvallate papillae. Immunoreactivity of VEGF weakened gradually in developing circumvallate papillae, and was restricted to epithelial tissue at the head of circumvallate papillae and some microvascular endothelial cells in fetal 28 weeks. On the other hand, the taste buds were observed at circumvallate papillae from fetal 16 to 28 weeks, and the immunoreactivity of VEGF was visible at a few cells in taste buds. With regard to the von Ebner's gland primordium, immunoreactivity of VEGF was found at all of the cells in glands. These results suggest that VEGF is concerned with the morphogenesis including the angiogenesis on circumvallate papillae. In addition, VEGF may play an important role in the differentiation of taste buds.
奥羽大学の論文