ラット新規細胞内物質virpsの高血圧症への関与 : Virps mRNA発現の本態性および二次性高血圧モデルにおける比較

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Hypertension patients have risks with respects to unexpected incidences in the cardio-vascular system during the anesthesia. Among 1015 incidences associated with anesthesia in Aichi Medical University Hospital for 2 years (June 2000-May 2002), cardiovascular incidences occurred at a rate of 26.9%, the most frequent, and respiratory ones at 18%. Among the cardio-vascular incidences, treatments were required for increment and decrement of blood pressure at a rate of 70%, and at less rates for bradycardia, tachycardia, arrhythmia, and cardiac arrest. Furthermore, the present study was undertaken to evaluate possible roles of virps, new intracellular compounds (virp 5 and naofen) cloned as verotoxin 2antibody reactive substances, in the development of hypertension. Two kinds of hypertension models have been utilized, a spontaneous hypertensive rat(SHR) model and a DOCA-induced hypertension one, compared with the control animals. Virps mRNA expressions in the aortic endothelial cells obtained in the DOCA-hypertension animals were obviously greater than those in SHR and normal. And the relaxations of isolated DOCA-treated rat aortic spiral strips induced by acetylcholine treated during the supra-maximal contraction with 10^<-5> M methoxamine were remarkably smaller than those obtained with SHR and normal animals. Pretreatment with a virp 5 peptide derivative (9 amino acids) or naofen-N terminal protein diminished the relaxation responses to acetylcholine, more greatly in SHR and normal rat aortic strips. These results indicated that virps may participate to the development of some kinds of hypertension such as the renal hypertension.
愛知医科大学の論文
2007-12-15

ラット新規細胞内物質virpsの高血圧症への関与 : Virps mRNA発現の本態性および二次性高血圧モデルにおける比較

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