33 Furanoid diterpenoid,Chettaphanin IおよびIIの構造

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概要

• 論文の詳細を見る

• 'Chettaphangkhi' is an indigenous drug applied for stmachics in Thailand and is obtained from the roots of Adenochlaena siamensis Ridl. From a methylene chloride extract, we have isolated three crystalline furanoditerpenoids, chettaphanin-I (1), chettaphanin-II (2) and anhydrochettaphanin-I (3) by column chromatography. The structures of these natural products were determined by spectroscopic analyses and chemical reactions. These compounds are members of rearranged labdane, and 2 is the novel furanoditerpene having a hydroacenaphthene skeleton. The structural relationship between 1 and 3 was provided by means of an acid catalyzed dehydration of 1. The structure of 2 was suggested by the fact that treatment of 1 with Zn-AcOH afforded 2, which was also derived from 3 by aldol condensation and hydrogenation, Intermediate (11) obtained in the alternate course for conversion of 1 to 2, was derived to a ketone (16) supporting the hydroacenaphthene skeleton of chettaphanin-II. The stereochemistry of these compounds is under investigation by X-ray analysis.

• 天然有機化合物討論会の論文
• 1970-10-01

著者

• 三島 洋

  三共中研

• 小木曽 彰

  Central Research Laboratories Sankyo Co. Ltd.

• 倉林 正明

  三共中研

• 小木曽 彰

  三共中研

• 佐藤 藹也

  三共中研

• 三島 洋

  Central Research Laboratories Sankyo Co. Ltd.

• 倉林 正明

  Central Research Laboratories Sankyo Co. Ltd.

• 佐藤 藹也

  Central Research Laboratories Sankyo Co. Ltd.

• 永堀 均

  三共中研

• 永堀 均

  Central Research Laboratories Sankyo Co. Ltd.

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