Mevalonolactone Derivatives as Inhibitors of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

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概要

• 論文の詳細を見る

• Mevalonolactone derivatives were prepared via stereo-and regioselective bromolactonization of γ, δ-unsaturated acids and their structure-activity relationship in connection with their inhibitory activity in vitro against 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, a rate-limiting enzyme in cholesterol biosynthesis, was investigated.

• 公益社団法人日本薬学会の論文
• 1980-05-25

著者

• 島田 葉子

  Fermentation Research Laboratories

• 三井 清司

  Central Research Laboratories

• 佐藤 藹也

  Central Research Laboratories Sankyo Co. Ltd.

• 金子 勲

  (Present address)College of Medical Technology, Kumamoto University.

• 金子 勲

  (present Address)college Of Medical Technology Kumamoto University.

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• Mevalonolactone Derivatives as Inhibitors of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase
• Isolation and Structure of Antipeptic Ulcer Diterpene from Thai Medicinal Plant
• The Structure of Toxic Components from Leucothoe Keiskei
• Novel Diterpenelactones with Anti-peptic Ulcer Activity from Croton sublyratus
• Synthesis of the Aglycones of Poriolide and Isoporiolide, New Biphenyl-type Flavanones
• 33 Furanoid diterpenoid,Chettaphanin IおよびIIの構造

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