14 フウトウカズラのアルカロイド、および、その他の成分について

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概要

• 論文の詳細を見る

• Piper futokadzura Zieb. et Zucc. (Piperaceae) is a common plant growing in the pacific coast of southern Japan, the leaves and stem of which are used as an indigenous medicine. As principles for the fragrant odor of this plant, α-pinene, camphene, β-pinene, sabinene, limonene and isoasarone were detected by means of fractional distillation and gas chromatography. Investigation of the ether extract of the leaves and stem led to the isolation of four new crystalline components designated as futoxide, C_<18>H_<18>O_8, m,p, 151-3°, futoenone, C_<20>H_<20>O_<5>, m.p. 197°, futoquinol, C_<21>H_<22>O_5, m.p. 97-8°and futoamide, C_<18>H_<23>O3N, m.p. 128-130°, besides β-sitosterol and stigmasterol. Futoxide was obtained in the highest yield of these components. These structures were determined by chemico-physical methods. Recently Kupchan et al isolated crotepoxide, having significant tumor inhibitory activity, from alcoholic extracts of the fruits of Croton macrostachys Hochst. ex A. Rich; (Euphorbiaceae). They elucidated the structure of crotepoxide by X-ray analysis. Comparison of futoxide with a sample of crotepoxide (by mixed m.p., mixed TLC, and IR spectral comparison) showed that the materials are identical.

• 天然有機化合物討論会の論文
• 1968-09-20

著者

• 高橋 秀次

  三共中央研究所

• 小木曽 彰

  Central Research Laboratories Sankyo Co. Ltd.

• 三島 洋

  Central Research Laboratories Sankyo Co. Ltd.

• 倉林 正明

  Central Research Laboratories Sankyo Co. Ltd.

• 三島 洋

  三共中央研

• 小木曽 彰

  三共中央研

• 倉林 正明

  三共中央研

• 高橋 秀次

  Central Research Laboratories, Sankyo Co., Ltd.

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