60(P29) イチゴ炭疽病菌Colletotrichum fragariaeの生産する新規自己発芽抑制物質Colletofragarone A1およびA2の化学構造(ポスター発表の部)

概要

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The conidia of a plant anthracnose fungus pathogenic to strawberry, Colletotrichum fragariae, germinate in water depending on the population, where the germination is inhibited under crowded conditions. The inhibition is considered to be caused by some germination-inhibiting substances exuded from conidia. Such germination self-inhibitors were searched for in the extract of the fungal culture and several active compounds were isolated. They were (E)- and (Z)-3-ethylidene-1,3-dihydroindol-2-one(1 and 2), (2R)-(3-indolyl) propionic acid(3), (2E,4E)-2,4-hexadienal(4) and two new compounds named colletofragarones Al(5) and A2(6). The structures of colletofragarones were determined spectroscopically to be tricyclic compounds with the molecular formulae of C22H26O6, respectively, which characteristically have a 10-membered ring lactone and a conjugated triene-containing side chain. The biosynthesis study using ^<13>C-labeled compounds revealed that all of the carbon atoms in colletofragarone were of acetate origin. HPLC analysis indicated that the compounds 1, 2, 5 and 6 were actually exuded from the conidia in water under crowded conditions, suggesting that these compounds control the conidial germination of this fungi.
天然有機化合物討論会の論文
1996-09-02