90(P02) ヒノキチオール錯体の抗菌性及び光安定性(ポスター発表の部)

概要

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We examined the photolysis characterstics and antibacterial activities of hinokitiol and its organometallic compounds that were obtained to react hinokitiol with metallic ions. As for photolysis, we found that the half-life period was 2.6 hours in hinokitiol. On the other hand, the half-life period were 1.8 days in the calcium salt, 2.2 days in the sodium salt, 6.5 days in the zinc salt and 42.9 days in the copper salt, respectively. So we found that the photolysis slowed about as many as 400 times at the copper salts. This is thought to be the obstraction of the generation of the valence isomer prepared because of an optical irradiation, tjhat is, result by the oxgen, s of the hydorxyl and the ketone of hinokitiol with a metallic ions. The antibacterial activities of hinokitiol and its organometallic commpounds were claified. Minimum inhibitory concentration (MIC) of hinokitiol, the sodium salt, the potassium salt, the calcium salt against bacteria were 25〜50μg/mL, that of the magnesium salt was 200μg/mL and that of H-Cu was 20μg/mL.
天然有機化合物討論会の論文
1998-08-31