29 南アフリカ産海洋ミミズcephalodiscus gilchristiから単離した,強力な細胞成長抑制物質cephalostatin類の化学(口頭発表の部)

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The marine worm order Cephalodiscida (Hemichordata phylum) contains two tubeliving genera occurring primarily at considerable depths in the Southern hemisphere. Initial investigation of bioactive constituents in this worm class (Pterobranchia) led to our discovery of the powerful murine P388 Lymphocytic leukemia (PS system) cell growth inhibitor cephalostatin 1 (1) in the South African (Indian Ocean) Cephalodiscus gitchristi. Subsequently, we isolated and assigned structures to the related disteroidal alkaloids cephalostatins 2(2), 3(3), and 4(4). We now report that further bioassay (PS) guided study of C. gilchristi has led to the isolation of two unusual disteroidal alkaloids bearing aromatic Crings designated cephalostatins 5(5) and 6(6) that retain significant cell growth inhibition (PS ED_<50> 10^<-2>μg/ml). With the X-ray crystal structure assigned cephalostatin 1(1) as a reference point, and the completely interpreted nmr spectra for cephalostatins 1, 2, 3, and 4, it became possible using detailed analysis of high field two-dimensional nmr data and the mass spectra, to unequivocally assign structures 5 and 6 respectively to cephalostatins 5 and 6.
天然有機化合物討論会の論文
1988-09-26