51 海洋産の抗腫瘍性物貭Bryostatinsの化学
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概要
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The sea-mat Bugula neritina (Linne) enjoys a broad geographic range in the oceans and is one of the more prominent Bryozoa species. We found that certain Bryozoa members including B. neritina L. contain potentially important antineoplastic constituents. By P-388 lymphocytic leukemia bioassay, the antineoplastic substances bryostatin 1, 2, 3, 4, 5, 6, 7, and 8 were isolated from Bugula neritina (the Florida, Mexican and Japanese species) and Amathia convoluta (another Bryozoa). The bryostatins were also found in the extract of the yellow sponge Lissodendoryx isodictyalis and the tunicate Aplidium californicum. Structures were shown in Chart 1. Also, three new bryostatins (9,10,and 11) were isolated from Bugula neritina and their structures were identified as indicated in Chart 2, based on the spectral data and chemical evidence. Occurrence of bryostatins in four animals was discussed.
- 天然有機化合物討論会の論文
- 1985-09-07
著者
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Pettit G.
アリゾナ州立大がん研
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Pettit G.
アリゾナ州立大ガン研
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釜野 徳明
アリゾナ州立大がん研
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Herald C.
アリゾナ州立大ガン研
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Leet J.
アリゾナ州立大ガン研
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釜野 徳明
アリゾナ州立大学ガン研究所
関連論文
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- 23 カリホルニア沿岸のフサコケムシBugula neritinaから得られた新抗腫瘍性物質Bryostatins,12と13の構造
- 51 海洋産の抗腫瘍性物貭Bryostatinsの化学
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- III. 海洋動物に抗腫瘍性物質を探る(第 2 回科学技術フォーラム「海洋資源」)(1987 年度科学技術フォーラム要旨)(I. 研究所報告)
- ステロイド・オレフィンのPrévost反応