23 カリホルニア沿岸のフサコケムシBugula neritinaから得られた新抗腫瘍性物質Bryostatins,12と13の構造

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Bryostatins 12 (12, 3.7mg) and 13 (13, 0.7mg) were isolated from〜1000kg of the marine bryozoan Bugula neritina (Linnaeus) found in the Eastern Pacific Ocean (California). The new bryostatins led to strong cell growth inhibitory (PS cell line ED_<50> 0.014 and 0.0054μg/mL) and antineoplastic activity (for bryostatin 12, a 47-68% increase in life extension at 30-50μg/kg) against the murine P388 lymphocytic leukemia (PS system). In addition to the previously known constituents, bryostatin 1(1), 2(2) and 3(3), of Bugula neritina from this ocean area the presence of bryostatins 8 (8, 13.2mg) and 9 (9, 16.4mg) were also established. A detailed series of ^1H-^1H-COSY, 2D-J-resolved, and ^1H-13-C-2D-shift correlated NMR experiments combined with ^<13>C-NMR and SP-SIMS studies were employed to elucidate the structures of bryostatins 12 (12) and 13 (13).
天然有機化合物討論会の論文
1986-09-09