62 サザエのホスホノスフィンゴ糖脂質の構造について(そのIII)

概要

論文の詳細を見る
From the viscera of T. cornutus the novel phosphoglycolipid was isolated. This lipid contained long chain bases, fatty acids, galactose and 2-N-methylaminoethylphosphonic acid in a molar ratio of 1:1:1:1. Partial acid hydrolysis with 2N HCl (100℃, 1.7hr) liberated galactose 2-N-methylaminoethylphosphonate which was established by GC-MS analysis. Alkaline hydrolysis with saturated Ba(OH)_2 (reflux, 6hr) yielded galactosylceramide as the main product. This lipid consumed two moles of periodate, and ceramide, glycolaldehyde and glyceryl 2-N-methylaminoethylphosphonate were obtained on Smith degradation. The structure of glyceryl 2-N-methylaminoethylphosphonate was established by GC-MS analysis. From these results, the structure of this novel lipid was determined to be 1-O-[6'-O-(2-N-methylaminoethylphosphonyl)-galactopyranosyl]ceramide. The fatty acid contained approximately equal amounts of nonhydroxy acids(mainly C_<16:0>) and 2-hydroxy acids(mainly C_<16:0>). The long chain bases were mainly dihydroxy bases with 16-22 carbon atoms. Small amounts of trihydroxy bases were also found.
天然有機化合物討論会の論文
1975-10-01