SD法による小児用抗菌薬の服用性評価

概要

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The purpose of the present study was to evaluate several factors affecting the palatability of 7 kinds of antibacterial formulation (azithromycin fine granules, clarithromycin dry syrup, cefditoren pivoxil fine granules, cefdinir fine granules, cefcapene pivoxil fine granules, erythromycin dry syrup, oseltamivir dry syrup) for pediatric use by the SD (Semantic Differential) method. There were 15 evaluation items altogether, consisting of 10 items obtained from gustatory sensation testing and 5 obtained from package inserts. Based on a principal ingredient analysis, items having a high factor loading were "palatability", "particle persistence in mouth", "feeling to tongue", "tendency to cause diarrhea", "bitterness (as suspension for 10 mins), "smell (as powder)", "ease of suspension", "drug-food/beverage interaction" and "familiarity of taste". The SD method proved useful in deriving factors affecting palatability, and using the high factor loading item scores, we were able to created overall palatability profiles graphically for the 7 types of antibacterial formulation for comparison purposes.
2008-03-10