急性中毒患者におけるp-クロロアニリン代謝物の尿中排泄量とその半減期

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The aim of this study was to elucidate the time courses of amounts of urinary p-chloroaniline (p-CA) metabolites during acute poisoning and to establish a suitable method for biological monitoring of exposure to p-CA. Urinary p-CA metabolites which were previously identified in a patient with acute p-CA poisoning were determined quantitatively over time during admission of a patient by high-performance liquid chromatography (HPLC) and by the colorimetric method of diazo-positive metabolites (DPM). The data of urinary excretion of each p-CA metabolite were fitted to two-compartment model of pharmacokinetics. Major urinary metabolites of p-CA were conjugated p-CA and conjugated 2-amino-5-chlorophenol (2-A-5-CP), and the detected amounts of 2,4-dichloroaniline (2,4-DCA) and free p-CA were small. During the rapid phase for the disappearance of each metabolite, half lives of p-CA, 2-A-5-CP and 2,4-DCA were 2.4, 1.7 and 1.7h, respectively, and during the slow phase, they were 4.5, 3.3 and 3.8h, respectively. Urinary p-CA occupied about 62% of the total metabolites detected in the urine, 2-A-5-CP about 36%, and 2,4-DCA about 1%. 2-A-5-CP and p-CA were detected in the urine of the patient obtained on days 3 and 4, respectively, after the poisoning, but the amount of DPM after the second day of the poisoning was in the ranged of that of non-exposed persons. As the colorimetric method was not accurate for biological monitoring at a low level exposure of p-CA, measurement of urinary p-CA or 2-A-5-CP by HPLC is considered to be more suitable for biological monitoring of p-CA exposure.
社団法人日本産業衛生学会の論文
1992-03-20

急性中毒患者におけるp-クロロアニリン代謝物の尿中排泄量とその半減期

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