Differential Role of Mitogen-Activated Protein Kinases in Response to Manganese Treatment in Substantia Nigra Dopaminergic Neurons
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概要
- 論文の詳細を見る
Recent studies have provided evidence that exposure to manganese (Mn) induces Parkinson's disease (PD)-like symptoms. We investigated the mechanism of Mn neurotoxicity in the SN4741 dopaminergic (DA) neuronal cell line. The results indicated that the p38 and c-Jun N-terminal kinase (JNK) mitogenactivated protein kinases were activated during DA cell death by MnCl_2. Moreover, p38 inhibition with SB203580, a specific inhibitor of p38, induced more toxic effects in MnCl_2-treated cells. Among the p38 subfamily members, p38α attenuated the caspase-3 activation and cell death induced by MnCl_2. However, the expression of JNK stimulated the activity of caspase-3 and mediated the Mn-induced cell death. These results suggest that there are multiple pathways in MnCl_2-induced DA neuronal cell death.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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KIM Seung
Department of Alternative Medicine, Gwangju University
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KIM Sung-Jun
Department of Biotechnology, Chosun University
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Chun Hong
Department Of Biotechnology (bk21 Program) Chosun University:research Center For Proteineous Materia
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Chun Hong
Department Of Biotechnology (bk21 Program):research Center For Proteineous Materials Chosun Universi
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Kim Seung
Dep. Of Alternative Medicine Gwangju Univ.
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Park Euteum
Department of Biotechnology (BK21 Program)
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Park Euteum
Department Of Biotechnology (bk21 Program):research Center For Proteineous Materials Chosun Universi
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Kim Seung
Department Of Alternative Medicine Gwangju University
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Kim Sung-jun
Department Of Biotechnology And Bk21 Research Team For Protein Activity Control Chosun University
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Kim Sung-jun
Department Of Alternative Medicine Gwangju University
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KIM Seung
Department of Allergy and Clinical Immunology, Ajou University School of Medicine
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