Design and Synthesis of New 2-Substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles as Anticonvulsant Agents
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概要
- 論文の詳細を見る
A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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Shafiee Abbas
Department of Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran Uni
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Zarghi Afshin
Department Of Medicinal Chemistry Shaheed Beheshti University Of Medical Sciences
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Shafiee Abbas
Department Of Medicinal Chemistry Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Te
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HAJIMAHDI Zahra
Department of Medicinal Chemistry, Shaheed Beheshti University of Medical Sciences
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MOHEBBI Shohreh
Department of Medicinal Chemistry, Shaheed Beheshti University of Medical Sciences
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RASHIDI Hootesa
Department of Medicinal Chemistry, Shaheed Beheshti University of Medical Sciences
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MOZAFFARI Sasan
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shaheed
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SARRAF Sahar
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shaheed
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FAIZI Mehrdad
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shaheed
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TABATABAEE Seyed
Department of Medicinal Chemistry, Shaheed Beheshti University of Medical Sciences
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Sarraf Sahar
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Shaheed B
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Faizi Mehrdad
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Shaheed B
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Tabatabaee Seyed
Department Of Medicinal Chemistry Shaheed Beheshti University Of Medical Sciences
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Hajimahdi Zahra
Department Of Medicinal Chemistry Shaheed Beheshti University Of Medical Sciences
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Rashidi Hootesa
Department Of Medicinal Chemistry Shaheed Beheshti University Of Medical Sciences
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Mozaffari Sasan
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Research Center Shaheed B
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Mohebbi Shohreh
Department Of Medicinal Chemistry Shaheed Beheshti University Of Medical Sciences
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