Radioprotective Effects of 2-Imino-3-[(chromone-2-yl)carbonyl] thiazolidines against γ-Irradiation in Mice

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A series of 2-imino-3-[(chromone-2-yl) carbonyl]thiazolidines substituted at the C-5 and / or C-7 positions of a chromone ring were synthesized. The in vivo toxicity and radioprotective efficacy of these agents were evaluated in male NMRI mice against cobalt-60 γ-rays. The LD_<50> values as determined by a Probit analysis, were 659, 1216 and 790 mg/kg for compounds, 2, 3 and 4, respectively. For studying radioprotective effects, one half of the toxic LD_<50> values were used, namely 330, 605 and 395 mg/kg for compounds 2, 3 and 4, respectively. The dose reduced factor (DRF) was determined by dividing the LD_<50/30> values obtained from the radiation survival curve in the presence of a radioprotective agent by the LD_<50/30> value obtained from a control radiation survival curve. A compound with a hydroxyl group substituent at the C-5 position afforded better radioprotective activity than those without this substituent. The radioprotective effect of chromone having a hydroxyl group at only the C-7 position was similar to that of the unsubstituted chromone. The most active compound has hydroxyl groups at the C-5 and C-7 positions of the chromone ring; it had a DRF of 1.48.