Radioprotective Effects of Citrus Extract Against γ-Irradiation in Mouse Bone Marrow Cells
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概要
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The radioprotective effects of citrus extract were investigated by using the micronucleus test for anticlastogenic and cell proliferation activity. A single intraperitoneal (i.p.) injection of citrus extract (Citrus aurantium var. amara) at 250, 500, 1,000 mg/kg body weight 1 h prior to γ-ray irradiation (1.5 Gy) reduced the frequencies of micronucleated polychromatic erythrocytes (MnPCES) and normochromatic erythrocytes (MnNCES). All three doses of citrus extract significantly reduced the frequencies of MnPCEs and MnNCEs in mice bone marrow compared to non-drug-treated irradiated control (p < 0.005-0.05). The optimum dose for protection in mouse was 250 mg/kg to protect mice bone marrow 2.2-fold against the side effects of γ- irradiation with respect to the non-drug-treated irradiated control. The flavonoids were contained in citrus extract, probably to show protective activity, and reduced the clastogenic effect of radiation on mice bone marrow. Therefore fruits and vegetables contain flavonoids to be useful as protective effects under such stress conditions as irradiation.
- 日本放射線影響学会の論文
著者
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Shafiee Abbas
Department of Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran Uni
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HOSSEINIMEHR SEYED
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences
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Shafiee Abbas
Department Of Medicinal Chemistry Faculty Of Pharmacy Tehran University Of Medical Sciences
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TAVAKOLI HASSAN
Departments of Physiology and Biophysic, Faculty of Medicine, Baghiatellah (A.S.) University of Medi
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POURHEIDARI GHOLAMREZA
Departments of Pharmacology, Faculty of Medicine, Baghiatellah (A.S.)University of Medical Sciences
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SOBHANI ALIGHOLI
Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences
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Sobhani Aligholi
Department Of Anatomy Faculty Of Medicine Tehran University Of Medical Sciences
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Hosseinimehr Seyed
Department Of Medicinal Chemistry Faculty Of Pharmacy Mazandaran University Of Medical Sciences
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Hosseinimehr Seyed
Department Of Medicinal Chemistry Faculty Of Pharmacy Mazandaran Universityof Medical Sciences
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Pourheidari Gholamreza
Departments Of Pharmacology Faculty Of Medicine Baghiatellah (a.s.)university Of Medical Sciences
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Tavakoli Hassan
Departments Of Physiology And Biophysic Faculty Of Medicine Baghiatellah (a.s.) University Of Medica
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