Formulation Approach for Nicorandil Pulsatile Release Tablet

スポンサーリンク

概要

• 論文の詳細を見る

• The purpose of this study was to obtain a nicorandil pulsatile release tablet that has a well-regulated release lag time. When nicorandil is used as an antiangina drug, administration time control is important. A pulsatile release tablet is one of the effective approaches to modified release to reduce daily administration frequency. In this study, a pulsatile release tablet of nicorandil was formulated by fumaric acid dry coating around the core tablet including nicorandil. The model tablets, which had different content ratios of excipients in the dry-coating layer, were characterized by a dissolution test. The results showed that the release lag time was generated with fast release profiles. Various lag time controls of tablets were achieved, from 60 to 310 min on average, by variation of outer layer composition. From an analysis of the relation between lag times and outer layer composition, the key ingredient for prolongation of lag time was found to be fumaric acid. To analyze the lag time generation mechanism, water penetration for tablet was measured. The results indicated that the penetration depth was proportionate to the square root of time and the lag time formation mechanism was simple water penetration through the matrix of fumaric acid to the tablet core. The results also showed that the Washburn equation could be used to design the lag time of the pulsatile release tablet in this study. In conclusion, novel release control technology using fumaric acid was appropriate to obtain a nicorandil pulsatile release tablet that has well regulated lag time.

• 公益社団法人日本薬学会の論文
• 2008-04-01

著者

• MAEDA Hiroyuki

  Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima Uni

• Terada Katsuhide

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Toho University

• Terada Katsuhide

  Department Of Pharmaceuticals Faculty Of Pharmaceutical Science Toho University

• OGAWA Yutaka

  Formulation Technology Research Department, Chugai Pharmaceutical Co., Ltd.

• ISHIYAMA Masato

  CMC Coordination and Planning Department, Chugai Pharmaceutical Co., Ltd.

• HIRAYAMA Tomoaki

  Formulation Technology Research Department, Chugai Pharmaceutical Co., Ltd.

• Ishiyama Masato

  Cmc Coordination And Planning Department Chugai Pharmaceutical Co. Ltd.

• Hirayama Tomoaki

  Formulation Technology Research Department Chugai Pharmaceutical Co. Ltd.

• Ogawa Yutaka

  Formulation Technology Research Department Chugai Pharmaceutical Co. Ltd.

• Maeda Hiroyuki

  Department Of Civil And Environmental Engineering Faculty Of Engineering National University Corpora

• Maeda Hiroyuki

  Department Of Pharmaceuticals Faculty Of Pharmaceutical Science Toho University:formulation Technolo

• MAEDA Hiroyuki

  Department of Chemistry, Materials Engineering, Kansai University

• MAEDA Hiroyuki

  Departhents of Biochemistry and Surgery, Fukui Medical School

関連論文

• Neutropenic Enterocolitis in Lung Cancer : A Report of Two Cases and a Review of the Literature
• Syntheses and Properties of a New Type of Lewis Acids Incorporating Linked Bisphenoxide Moiety
• Possible Involvement of Protein-Tyrosine Kinases Such as p72^ in the Disc-Sphere Change Response of Porcine Platelets
• A Novel Orthogonal Joint by Hydrogen Bonding. Pybox Ligand and Secondary Dialkylammonium Cation Complexes
• Formulation Approach for Nicorandil Pulsatile Release Tablet
• Low-Titer Cold Agglutinin Disease with Systemic Sclerosis
• Sarcoidosis with Multiple Organ Involvement Emerging as Lofgren's Syndrome
• Molecular State of Chlopheniramine in Resinates
• The Iwato Slide Has Characteristics of both Shear Zone Slide and Hydrothermal Alteration Zone Slide
• Joint Stiffness and Position Control of an Artificial Muscle Manipulator for Instantaneous Loads Using a Mechanical Equilibrium Model
• 北海道北見鉱床区隆尾鉱山地域の火山活動,熱水変質作用および浅熱水性金銀鉱化作用
• A LANDSLIDE CLAY OF THE SEMPOSHI SLIDE OCCURRED WITHIN THE SEMPOSHI FORMATION OF THE NEMURO GROUP IN THE WEST COAST AREA OF AKKESHI BAY, EASTERN HOKKAIDO, JAPAN
• The Relationship between the Yasukuni Slide and a Hydrothermal Interstratified Illite/Smectite Minerals Zone
• Comparative Study of Branded and Generic Formulations of Bromocriptine Mesylate
• A PALYGORSKITE VEIN FOUND IN CONGLOMERATE OF THE UPPER EOCENE-LOWER OLIGOCENE RIKUBETSU FORMATION IN NORTHEASTERN HOKKAIDO, JAPAN
• Characterization of Non-stoichiometric Hydration and the Dehydration Behavior of Sitafloxacin Hydrate
• イオン交換法によるLiNi.Mn.O正極材料のイオン分布と電気化学特性
• 北海道北見鉱床区武華鉱山地域の火山活動,熱水変質作用および浅熱水性金銀鉱化作用の関係
• Interplay of Charge-Density Wave and Magnetic Order in Ternary Rare-Earth Nickel Carbides, RNiC
• Sarcoidosis with Multiple Organ Involvement Emerging as Loefgren's Syndrome

もっと見る 閉じる

スポンサーリンク