Molecular State of Chlopheniramine in Resinates
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概要
- 論文の詳細を見る
Chlorpheniramine (CPM) maleate was prepared as a series of resinates by the batch method. The several resinates were investigated by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and infrared (IR) spectrometry. The results from DSC and XRPD showed that the molecular state of the entrapped drug changed from the crystalline to amorphous state. IR spectra indicated that only CPM species was entrapped in the resinates. Moreover, it also showed that the positively charged amine group of the drug interacted with the sulfonate groups of the resin by ionic association. The dissolution of the drug and resinates was also studied where it was found that the dissolution of the resinates was retarded by their corsslinked structure and markedly affectd by the quantity of resin.
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
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Yonemochi Etsuo
Department Of Pharmaceutics School Of Pharmaceutical Sciences Toho University
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Terada Katsuhide
Department Of Pharmaceuticals Faculty Of Pharmaceutical Science Toho University
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Terada Katsuhide
Department Of Pharmaceutics School Of Pharmaceutical Sciences Toho University
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AKKARAMONGKOLPORN Prasert
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University
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Akkaramongkolporn Prasert
Department Of Pharmaceutical Technology Faculty Of Pharmacy Silpakorn University
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