機能性便秘者に対する低分子化アルギン酸ナトリウムおよびグアーガム部分分解物の混合物の便通ならびに腹部不快感の改善に関する最小有効量の検討

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The minimal effective dose was evaluated of a mixture (AG) containing depolymerized sodium alginate as non-fermentable dietary fiber and partially hydrolyzed guar gum as fermentable dietary fiber at a weight ratio 3 to 2 to treat defecation and abdominal discomfort in females (n=60) suffering from functional constipation and low frequency of defecation (≤4 days/week). Clinical testing used a single blind-dose escalation regime. The experimental duration was 14 weeks, constituting four consecutive periods: the observation period (2 weeks); and three periods of AG administration as a 200-ml beverage in doses of O g (4 weeks), 2.5 g (4 weeks) and 5 g (4 weeks). The frequency of defecation (numbers of days and times) and the fecal weight of the study subjects (n=42) were significantly higher, and the score for abdominal discomfort significantly lower during the 5-g AG administration period than the O-g period. There were no clinical problems for any of the subjects (n=60) during the administration period. These results suggest that the intake of at least 5 g of AG can increase the defecation frequency and effectively reduce the abdominal discomfort for some people who experience functional constipation.
社団法人日本家政学会の論文
2008-03-15