ニューロン群の活動計測と解析

概要

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In biological systems, information is stored and processed simultaneously in the same neuronal networks. The networks consist of a large number of neurons and their mutual connections. The weights of distributed synapses are adjusted in an activity-dependent manner during development as well as in matured neuronal networks. To see activity of neuronal ensembles, one of the promising methods is micro-electrode array (MEA) based recording. The advantages of the MEA are noninvasiveness and the capability of multi-site stimulation. In this paper, based on the advantages described above, two aspects of MEA-based recording are reported. First, developmental changes of spontaneous activity in cortical neurons are shown. Rat cortical neurons are cultured on MEAs and the spontaneous activity is continuously monitored for two months. The second one is application of multi-site stimulation to visualize tetanus-induced modification of evoked activity. A focal tetanic stimulation is applied to cultured cortical neurons and how this tetanus affects 64 kinds of evoked activity is studied.
2006-09-25