723 細胞外基質の力学的性質と毛細血管ネットワーク形成(S08-1 細胞の構造とメカノバイオロジー(1),S08 細胞の構造とメカノバイオロジー)

概要

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We clarified the effect of mechanical property of substrate on the microvessel network formation by cultured Bovine Pulmonary Microvascular Endothelial Cells (BPMECs). The type I collagen gels, with different elasticity were polymerized at pH 5 (E=4500±1500Pa ; flexible gel), at pH 9 (E=20800±3100Pa ; rigid gel). In the flexible gel, network structure formed by connection between elongated and sprouting cells and network density is larger. The cells in the rigid gel tend to generate aggregates. Furthermore we confirmed the lumen surrounded with a single cell for flexible gel and lumen surrounded by two cells in rigid gel. Thus this result demonstrated that the mechanical property of extracellular matrix greatly plays a major role for the network formation.
社団法人日本機械学会の論文
2006-09-15