217304 生体吸収性薄膜による胆管上皮細胞の管腔構造形成(OS07 細胞・生体組織3,オーガナイズド・セッション)

概要

論文の詳細を見る
In this study, we reconstructed bile ducts by biliary epithelial cells (BECs) between collagen gel and a biodegradable poly(lactic-co-glycolic acid) (PLGA) membrane. We found that the density of collagen coating on the PLGA membrane as well as the membrane porosity affected the BEC morphogenesis. In particular, bile ducts formed with a non-porous membrane were larger than those formed with a porous membranes. In addition, only BECs contacted with a PLGA membrane formed bile ducts. Reconstructed bile ducts were maintained in culture even after a PLGA membrane was degraded. These results suggest that this culture system can be extended to co-culture of bile ducts and the second cell type with direct contacts.
一般社団法人日本機械学会の論文
2011-03-17