Thermodynamics of DNA Condensation Caused by Mn^<2+> Binding

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概要

• 論文の詳細を見る

• Interaction between Mn^<2+> ion and the two forms of DNA duplex (supercoiled and linearized pUC119 DNA) in solution has been examined by isothermal titration calorimetry. Although DNA condensation reaction heat was observed at 323K, this was not the case at 298K. DNA condensation was entropically driven and supercoiled DNA was found to be more susceptive. The enthalpy of DNA condensation is estimated 0.42kJ/mol for both DNA forms. Conversely, the entropy of DNA condensation was 0.13kJ/molK for supercoiled DNA, and 0.12kJ/molK for linearized DNA. The difference of entropy is attributable to their DNA conformation.

• 公益社団法人日本薬学会の論文
• 2008-03-01

著者

• UTSUNO Kuniharu

  Department of Fundamental Science, Iwaki-Meisei University

• Utsuno Kuniharu

  Department Of Science And Engineering For Materials Tomakomai National College Of Technology

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• Thermodynamics of DNA Condensation Caused by Mn^ Binding

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