Viewing of Complex Molecules of Ethidium Bromide and Plasmid DNA in Solution by Atomic Force Microscopy
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概要
- 論文の詳細を見る
Tertiary structure changes in plasmid DNA, induced by ethidium bromide intercalation, have been observed in aqueous solutions by the use of an atomic force microscope. A relaxed closed circular pBR322 molecule became a positively supercoiled complex on the drug binding. The supercoiling always resulted in an interwound(or a plectonemic)form, but never a solenoidal(or a toroidal)form. A quantitative analysis of the compactness of such supercoiled complexes has been carried out.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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Utsuno K
High-tech Research Center College Of Science And Engineering Iwaki Meisei University
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Iwamoto T
High-tech Research Center College Of Science And Engineering Iwaki Meisei University
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UTSUNO Kuniharu
High-Tech Research Center, College of Science and Engineering, Iwaki Meisei University
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TSUBOI Masamichi
High-Tech Research Center, College of science and Engineering, Iwaki Meisei University
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KATSUMATA Shunji
High-Tech Research Center, College of Science and Engineering, Iwaki Meisei University
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IWAMOTO Toschitake
High-Tech Research Center, College of Science and Engineering, Iwaki Meisei University
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UTSUNO Kuniharu
Department of Fundamental Science, Iwaki-Meisei University
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Katsumata S
High-tech Research Center College Of Science And Engineering Iwaki Meisei University
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Tsuboi M
High-tech Research Center College Of Science And Engineering Iwaki Meisei University
関連論文
- Visualization of Complexes of Hoechst 33258 and DNA Duplexes in Solution by Atomic Force Microscopy
- Viewing of Complex Molecules of Ethidium Bromide and Plasmid DNA in Solution by Atomic Force Microscopy
- How and How Much Can Hoechst 33258 Cause Unwinding in a DNA Duplex?
- The Average Unwinding Angle of DNA Duplex Produced by the Binding of Chromomycin A_3
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